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Microglial ferroptosis has been shown to induce neurotoxic astrocytes through pro-inflammatory signaling (such as IL-6 and TNF-), and ferroptosis-related genes including ACSL4 and GPX4 are highly enriched in microglia within HD lesions

While insomnia is not listed among common adverse reactions in FDA prescribing information or major clinical trials, some patients report sleep disturbances during treatment

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