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We therefore suggest for future studies on monothiol mechanism (i) to take the bulkiness of the putative Grx(SSR) intermediate, an S N 2 reaction geometry, and a possible accumulation of Grx(SSR) as an artifact into account (Fig
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Oral glutathione is subject to degradation by digestive enzymes, and early studies found that a single oral dose of up to 3,000 mg failed to increase plasma glutathione levels in healthy volunteers [1][13]
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