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However, the optimal dosage, administration route and long-term safety of NADPH precursors remain unvalidated in large animal models, and the crosstalk of NADPH metabolism, iron homeostasis and retinal inflammation is poorly understood, limiting clinical translation of NADPH-targeted therapies and requiring further investigation
Emerging evidence indicates that the endogenous synthesis of glycine may not meet the demand of farmed animals (e.g., HSB and growing pigs) under various nutritional and physiological conditions [13, 14, 27]
Lee et al., 2022)
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