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Rajakovich LJ, Fu B, Bollenbach M, Balskus EP Proceedings of the National Academy of Sciences of the United States of America 2021
Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
E., Rosenstock, J
Established and Potential Benefits Acetyl-L-Carnitine (ALC or ALCAR) continues to be a molecule of great interest to researchers because so many important functions have been identified in preclinical research
doi: 10.1016/S0014-5793(02)02918-6 108 MillsPDominiqueJCLafrenireJFBouchentoufMTremblayJP
