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Tier 2 conditions in detail: Heart failure with preserved ejection fraction (HFpEF) HFpEF is heart failure with a left ventricular ejection fraction of 50 percent or higher on echocardiogram

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Unlike other drug trials, integrative oncology studies encounter additional methodological issues such as the plethora of supplement formulations and their composition, variability in concentration of bioactive compounds across different source materials, patient-driven simultaneous use of products and multifaceted endpoints that include tumour response objective assessments as well as symptom control, quality-of-life evaluation, and biomarker modification (19)

doi:10.1677/jme.0.0210235

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