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The 2010s introduced gene-expression analysis: data generated through the Broad Institute's Connectivity Map indicated that GHK exposure modulated expression of 4,192 of the 13,424 human genes assayed, with approximately equal up- and down-regulation across stress-response, inflammation, and tissue-repair pathways [2]
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Activation of MC1R is thought to initiate cyclic AMP mediated signaling cascades that may influence transcriptional regulators such as microphthalmia associated transcription factor, which is associated with enzymes involved in eumelanin production
This effect is mediated through both metabolic and epigenetic mechanisms
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