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Dietary deficiency versus malabsorption When low intake is the suspected cause Diet-related deficiency can occur when a person does not regularly obtain enough vitamin B12 from food or fortified products

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Avoid alkaline solvents and buffers: NAD+ is comparatively stable in acid but hydrolyses in base at both the nicotinamide-ribose glycosidic bond and the pyrophosphate linkage, and NADH behaves in the opposite direction