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It is important to note that individual experiences vary considerably, and not all patients experience these sensations

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Serious adverse effects including signs of pancreatitis, gallbladder disease, or severe allergic reaction require immediate medical attention

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Thus, in order to have GLP/GIP analogs with lasting effects, alterations of the peptides needed to be made in order to prevent their rapid metabolism by DPP-4 and oral administration could not be used

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