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Initially, approximately 25 patients were recruited per group to account for potential withdrawals or loss to follow-up

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Recently, primary cells from the mucoid tissue of the nose septum, the nasal epithelium of the nose cavity, or the concha inferior grown on the ALI system were tested for barrier function after meningococcal infection ( Table 1 , the potential crossing route exploited seems to be dependent on the meningococcal strain, with strains belonging to cc32 and cc22 more likely to follow the transcellular route, while those belonging to cc11 more likely to follow the paracellular route

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