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Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes
If a dose increase causes intolerable GI symptoms, the Phase 2 protocol explicitly permitted returning to the prior dose level and waiting a full 4 weeks before re-attempting escalation
While its effective for blood sugar control, its weight loss results are modest compared to newer options
Documentation of metabolic improvementsincluding changes in hemoglobin A1c, lipid profiles, and blood pressureprovides additional evidence of treatment benefit and may motivate continued adherence to therapy
You may have heard the term microdosing connected to certain psychedelic drugs
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